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Subsequent investigations revealed that c9,t11-CLA effectively suppresses the expression of pro-inflammatory factors, chemokines, and ICAM-1 by inhibiting NF-B transcriptional regulation and dampening MAPK signaling pathway activity, thus exhibiting potent anti-inflammatory properties

Only in the 20th century were the pathways of production of uric acid in the body truly understood and clarified, and it was proved that uric acid crystals have the ability to produce joint inflammation